cGMP Facility • Texas
(844)-323-5628
Supplements Manufacturing

Tablet Manufacturing & Rotary Compression

Film-coated, chewable, bi-layer, and sublingual tablet production on high-speed rotary presses.

MNL's tablet manufacturing division operates multi-station rotary tablet presses capable of standard, bi-layer, and mini-tablet formats. We provide complete direct-compression and wet-granulation pathways, with film-coating capability for moisture barriers, enteric coatings, and brand-color cosmetic finishes. All tablet runs include hardness, friability, disintegration, and weight uniformity testing per USP compendial methods.

Request a Production QuoteConsult Technical Team

Supported Dosage Forms & Formats

Standard Compressed Tablets (all sizes)Film-Coated Tablets (moisture barrier, brand-color finish)Chewable Tablets (flavored, softened excipient matrix)Sublingual Tablets (fast-dissolve buccal matrix)Enteric-Coated Tablets (delayed-release)Bi-Layer Tablets (dual-phase release)Mini-Tablets (pediatric / multi-pellet fill)

Quick Fact Sheet

Key production parameters

Minimum Order Quantity

2,000 finished units

Standard Lead Time

5–7 weeks from formula approval and PO

Cleanroom Standard

ISO Class 8 / 21 CFR Part 111 cGMP

Packaging Compatibility

  • HDPE Bottles (child-resistant and senior-friendly caps)
  • Blister Packaging (via partner network)
  • Amber Glass Bottles
  • Bulk Drums (pharmaceutical-grade HDPE)
  • Foil Sachets (unit-dose or multi-dose)
  • Stand-Up Resealable Pouches

Mutual NDA Standard: All formula details, BOM data, and brand concepts shared during the quoting process are protected under a reciprocal Non-Disclosure Agreement executed before technical evaluation begins.

Laboratory Asset Pipeline

Machinery & Specimen Visual Verification

Inspect actual cleanroom machinery, finished dosage macro specimens, and packaging protocols dedicated to tablet manufacturing & rotary compression.

Crisp white scored pharmaceutical tablets on sterile surface
Specimen Macro
Hardness: 8-18 kp | Friability < 0.5% (USP <1216>)

Precision-Compressed Scored Tablets

Direct-compression multivitamin tablets with precise break-scores and aqueous film coatings.

Cleanroom environment with automated tablet presses and dust collectors
Machinery Suite
ISO Class 7 Cleanroom | +20 Pa Positive Pressure

Rotary Tablet Press Suite

Multi-station rotary tablet press operating inside Class 10,000 positive-pressure cleanroom suites.

Amber glass and HDPE supplement bottles with pharmaceutical labels
Packaging & QA
Child-Resistant CRC Closures | Moisture Barrier Seal

UV-Blocking Amber Glass & HDPE Packaging

Medical-grade HDPE jars and amber glass bottles fitted with child-resistant caps and induction seals.

Engineering Specification Table

ParameterSpecification / ValueNote
Minimum Order Quantity (MOQ)
2,000 units
MNL SPEC
Tablet Press Type
Multi-station rotary press (direct compression + wet granulation)
MNL SPEC
Tablet Hardness Range
4 – 20 kP (configurable per formulation)
MNL SPEC
Friability Limit
≤ 1.0% weight loss per USP <1216>
MNL SPEC
Weight Variation Tolerance
±5% of mean tablet weight per USP <905>
MNL SPEC
Disintegration Time (uncoated)
≤ 15 minutes per USP <701>
MNL SPEC
Disintegration Time (film-coated)
≤ 30 minutes
MNL SPEC
Coating Pan Capacity
Up to 150 kg per coating batch
MNL SPEC
Cleanroom Classification
ISO Class 8 / 21 CFR Part 111 cGMP
MNL SPEC
Standard Batch Lead Time
5–7 weeks from formula lock and PO confirmation
MNL SPEC

Specifications are representative of standard production parameters. Project-specific values may vary based on formula requirements, ingredient characteristics, and target packaging format. Contact our engineering team for exact specifications relevant to your batch.

Quality Assurance & Verification Protocol

Every tablet manufacturing & rotary compression batch passes through a four-phase analytical verification workflow before Certificate of Analysis issuance and release.

01

Raw Material & Granulate Qualification

Pre-blend raw material identity and purity confirmed. For wet-granulation pathways, intermediate granulate moisture content is measured and controlled before compression.

Raw material COA and identity verificationGranulate moisture (LOD / Karl Fischer)Particle size distribution (PSD) of blendBlend uniformity assay (BU sampling per ASTM E2810)
02

In-Process Compression Controls

Real-time tablet press instrumentation monitors punch force, ejection force, and tablet weight. Hardness and friability sampled at defined intervals throughout the run.

Tablet weight uniformity (every 30 min per USP <905>)Hardness (Schleuniger / Erweka hardness tester)Friability per USP <1216> at batch start and mid-runDisintegration per USP <701>
03

Coating Validation & Finished QC

For coated tablets, coating weight gain is tracked per pan load. Appearance, color, and surface defect audit performed on finished tablets. Dissolution profiling available on request.

Coating weight gain % vs. theoreticalAppearance inspection (defects: capping, picking, sticking)Label claim potency (HPLC)Dissolution profiling USP <711> (on request)Microbial enumeration (TPC, E. coli, Yeast & Mold)
04

COA Release & Batch Documentation

Full batch manufacturing record and QA review. QA Director issues COA after all test results meet specification. Batch history traceability maintained per 21 CFR 111.

Complete batch record QA sign-offCOA issuance with lot, expiry, and test resultsRetain sample archival (21 CFR 111)Client release notification and COA transmittal

Certificate of Analysis (COA) — Issued Per Batch

Every commercial batch receives a QA Director–signed Certificate of Analysis on MNL letterhead. The COA documents all test parameters, analytical methods, results versus specification, and full lot traceability to raw material COAs. No batch ships without COA authorization.

Production Specification Request

Request a Quote for Tablet Manufacturing & Rotary Compression

Submit your project brief through our structured multi-step quote engine. Pre-select Tablet Manufacturing & Rotary Compression as your target manufacturing service. Our Carrollton, TX formulation and production team will provide a preliminary feasibility response within 24–48 business hours, under mutual NDA before any formula details are exchanged.

  • Preliminary quote returned within 24–48 business hours
  • Mutual NDA executed before formula review
  • Direct access to MNL formulation chemists
Request Quote for Tablet Manufacturing & Rotary Compression

Or contact our engineering team directly

(844)-323-5628info@micellecosmeticslabs.com

Mon – Fri: 8:00 AM – 5:00 PM CST. Facility visits by advance appointment.

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